The occurrence of the phylloxera disease almost completely destroyed authentic varieties of grapes, such as: Zilavka (vitis vinifera), Stanushina, Dimiat (Plovdina) Belerce, Sivjak… causing a devastating blow to the wine-producing industry widely in the region. However, the wine-growers and wine-producers from the Tikvesh region united and brought the American hybrid grape varieties which revived wine-producing in the Tikvesh region.
